prevalence and antimicrobial susceptibility pattern of extended spectrum beta lactamase (esbl) and non-esbl producing enteric gram-negative bacteria and activity of nitrofurantoin in the era of esbl
نویسندگان
چکیده
conclusion although all esbl producer gram-negative bacteria were sensitive to imipenem, piperacillin-tazobactam, and colistin, non-esbl isolates showed resistant pattern. interestingly, notable percent of mentioned resistant isolates were sensitive to nitrofurantoin. background resistance in enteric gram-negative bacteria is of a great concern and concise local data are lacking. objectives to determine prevalence and antimicrobial susceptibility pattern of extended spectrum beta-lactamase (esbl) and non-esbl producing enteric gram-negative bacteria. materials and methods in a descriptive study in tehran, patients’ samples have been obtained and were inoculated on blood and macconkey agar plates at microbiology laboratory hospital, and a total of 292 gram-negative species were isolated at microbiology laboratory from patients’ specimens. susceptibility pattern was determined by disk diffusion method based on kirby-bauer method on mueller-hinton agar plate. spss 16 software (descriptive analysis, chi-square) was used for statistical analysis of this study. results escherichia coli was the most common organism [189 (64.7%)], followed by acinetobacter baumannii [40 (13.7%)], pseudomonas aeruginosa [32 (11%)], klebsiella pneumoniae [26 (8.9%)], proteus mirabilis [4 (1.4%)], and serratia marcescense [1 (0.3%)]. 122 (41.8%) of isolates were classified as esbl - producers. e. coli accounted for most of the esbl-producer bacteria, followed by k. pneumoniae. 170 (58.2%) of isolates were non-esbl producers. all of the esbl producer isolates were sensitive to imipenem, piperacillin-tazobactam and colistin whereas resistance to these antibiotics in the non-esbl group was seen. the rate of resistance to nitrofurantoin in esbl group was lower than of that in non-esbl group. the majority of the esbl isolates of resistant to trimethoprim-sulfamethoxazole, ciprofloxacin, the third generation cephalosprins (ceftriaxone, cefixime, and cefotaxime), gentamicin and amikacin, were sensitive to nitrofurantoin.
منابع مشابه
Prevalence and Antibiotic Resistance Pattern of Extended Spectrum β-Lactamase- (ESBL-) Producing Gram Negative Bacilli isolated from Clinical Samples of hospitalized Patients in a hospital in Gorgan
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عنوان ژورنال:
jundishapur journal of microbiologyجلد ۶، شماره ۷، صفحات ۰-۰
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